②在2004年至2014年期间，对36例患者进行了回顾性评估:一些患者表现出食用榛子的症状，另一些患者则因为对另一种坚果过敏而避免食用榛子。诊断是通过皮肤点刺试验、全榛子提取物特异性IgE和Cor a1、Cor a8、Cor a9、Cor a14特异性IgE检测进行的，所有患者(除过敏反应病例外)进行口服榛子挑战试验。③36例患者中有28例(78%)食用榛子出现症状，18例(64%)确诊为榛子过敏。其中9例对Cor a 8(50%)敏感，2例对Cor a 1(11%)敏感，2例对Cor a 9(11%)敏感，2例对Cor a 14(11%)敏感。36名患者中有8人(22%)因为对另一种坚果过敏而不吃榛子。经口服试验证实3例榛子过敏。这3人中有2人对Cor a 8(66%)敏感，而没有一个对Cor a 1、Cor a 9或Cor a 14敏感。④ Cor a8(脂质转移蛋白)是西班牙两组榛子过敏患的最重要的过敏原，两组榛子过敏患者包括: 摄入榛子有症状的患者和因对另一种坚果过敏而规避摄入榛子的患者。
Component-Resolved Diagnosis in Hazelnut Allergy
Tree nuts allergy is one of the most common food allergies. In our study we evaluate the sensitization profile in our population.
36 patients were retrospectively evaluated between 2004 and 2014: some presented symptoms eating hazelnuts and others avoided hazelnuts because were allergic to another nut. The diagnosis was made by prick-prick Specific-IgE to full hazelnut extract and Cor a 1 , Cor a 8 , Cor a 9 , Cor a 14 and in all patients ( except cases of anaphylaxis ) oral challenge with hazelnut was made.
28 of 36 (78%)patients had symptoms eating hazelnuts and the diagnosis of hazelnut allergy was confirm in 18 patients (64%). 9 of these 18 were sensitizated to Cor a 8 (50%) , 2 of these 18 to Cor a 1 (11%) 2 of 18 to Cor a 9 (11%) and 2 of 18 to Cor a 14 (11%). 8 of 36 patients (22%) avoided hazelnuts because were allergic to another nut. Hazelnut allergy was confirmed in 3 cases by an oral challenge. 2 of these 3 were sensitizated to Cor a 8 (66%) and noone to Cor a 1, Cor a 9 or Cor a 14.
Cor a 8 (lipid transfer protein), was the most important allergen in our population of hazelnut allergic patients, in both groups, patients who had symptoms with the intake of hazelnut, and patients who avoided the intake because were allergic to another nut.
Ismael Garcia-Moguel, Cinthia De la cruz, Natividad De Las Cuevas, PhD, Ramón Vives Conesa
, MD, Jesus F. Fernandez Crespo, MD, Maria Del Carmen Dieguez, MD, PhD